Research suggests that physical affection sharing in romantic relationships is associated with physical, psychological, and relational well-being. However, the extent to which these associations generalize to interracial relationships is unclear in existing research. Although interracial relationships are becoming increasingly common and there is some evidence to suggest that acceptance of these relationships is increasing, stigma and prejudice toward interracial couples remain. The objective of this thesis was to examine public affection sharing in interracial and intraracial mixed-sex couples. This thesis consisted of two studies. Study 1 examined interracial and intraracial experiences with public affection sharing, affection-related vigilance, and self-reported physical, psychological, and relational well-being via an online survey (n = 1386; 19% interracial). Those in interracial relationships reported higher affection-related vigilance when general vigilance was controlled. There were also disparate associations between public affection sharing and physical and psychological well-being, respectively. Whereas the association between public affection sharing and physical well-being was neutral for those in intraracial relationships, it was negative for those in interracial relationships. As for psychological well-being, the association with public affection sharing was positive for those in intraracial relationships, and marginally negative for those in interracial relationships. Additionally, the respective associations between public affection sharing and psychological and relational well-being were moderated by affection-related vigilance, with weaker or more negative associations among those with higher levels of affection-related vigilance. Study 2 further examined public affection sharing in interracial and intraracial relationships via semi-structured interviews (n = 40; 58% interracial). A thematic analysis resulted in 12 themes with considerations that were either internal to the relationship, external to the relationship, or intermediary (i.e., consisting of both internal and external considerations). Internal themes included “Personal Preference,” “Relationship Dynamics,” “Feasibility and Convenience.” Intermediary themes included “Safety and Well-Being,” “Context Matters,” “Cultural Considerations,” and “Racial Experience.” External themes included “Relationship Optics,” “Others’ Attitudes,” “Impact of Others’ Attitudes,” “Social Influences,” and “Navigating Public Spaces.” The qualitative data provided further context for understanding Study 1 results, as there were more prominent differences between the two relationship types among some intermediary (i.e., Safety and Well-Being and Racial Experience) and all the external themes. Thus, Study 2 results suggest that the health disparities found in Study 1 are likely driven by a higher potential for those in interracial relationships to experience adverse reactions or views toward their public affection, or their relationship more generally, in some cases impeding on people’s sense of safety in public contexts. Although there were some differences observed, most participants in both relationship types expressed the subjective view that their racial make-up did not impact their public affection sharing in a meaningful way. Overall, these studies expand on theoretical models linking affection sharing to well-being and highlight the value of examining theories in diverse populations while gaining subjective views related to the research questions.