Photophysical investigation of coordination complexes for application in photodynamic therapy
LE3 .A278 2013
Bachelor of Science
The photophysical properties of twenty-five ruthenium and nine osmium polypyridyl coordination complexes were determined and analysed in the context of application to photodynamic therapy for the treatment of cancer. Of the primary compounds investigated, thirty were mononuclear compounds consisting of one metal and three bidentate ligands, while four were dinuclear compounds consisting of two metals con-nected by a bridging ligand and each metal stabilized by two bidentate ancillary ligands. Of interest are the absorption and emission properties of these compounds as they allow for elucidation of the excited state dynamics of the compound and offer insight on the mechanism of photodynamic damage—both key pieces of information for the intelligent design of future photodynamic compounds. Focus is given to the development of coordination complexes absorbing and achieving photodynamic ac-tion with red/NIR light—the portion of the electromagnetic spectrum that offers the greatest tissue penetration. The effects of subtle modifications are examined in order to provide insight on how to best modify the structure of the compounds to achieve efficient photodynamic action. The emission properties of the compounds are exam-ined in detail with the focus being on providing information about the nature of the excited state and how deactivation of the excited state may result in photodynamic action. Of particular interest is the ability of the compounds to transfer energy to ground state oxygen to produce singlet oxygen and transfer electrons, in the context of self quenching or otherwise.
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